Analytical Chemistry is a peer-reviewed research journal that is devoted to the dissemination of new and original knowledge in all branches of analytical chemistry. Fundamental articles may address the general principles of chemical measurement science without directly studying existing analytical methodology as long as what is discussed relates to an important chemical parameter. Articles may be theoretical or they may report experimental results. They may contribute to any phase of analytical operations including sampling, measurements, and data analysis; the articles should target fields including, but not limited to, bioanalytical chemistry, bioengineering, chemical analysis, environmental sciences, forensics and medical sciences. Topics commonly include chemical reactions and selectivity, chemometrics and data processing, electrochemistry, elemental and molecular characterization, imaging, instrumentation, mass spectrometry, microscale and nanoscale systems, -omics, sensing, separations, spectroscopy, and surface analysis. Papers dealing with established analytical methods need to offer a significantly improved, original application of the method.