研究报道小麦串联激酶激活NLR触发免疫

Brande是麦串激酶激活NLR免疫的结果。 B. H. 经过不懈的努力，Wulff团队取得了成功。这一最新研究成果于2025年3月28日发表的《科学》杂志。

研究小组发现，SR62位点是一个编码Sr62TK和NLRR。 (Sr62NLR)基因模块，并对相应的AvrSr62效应子进行鉴定。结合Sr62TK的N端激酶1，AvrSr62触发了激酶2的位移，从而激活了Sr62NLR。这是由于建模和突变分析。(i)激酶1和激酶2结合AvrSr62和激酶2。(ii)由激酶1和Sr62NLR的激酶2重叠结合位点引导。了解这种组分抗性复合体可能有助于设计和繁殖具有长期抗性的植物。

据报道，核苷酸与富亮氨酸重复序列相结合(NLR)在植物免疫中，受体的作用已经得到了很好的研究，但是一种串联激酶(TKs)给予小麦和大麦抗病能力的作用尚不清楚。

附：英文原文

Title: A wheat tandem kinase activates an NLR to trigger immunity

Author: Renjie Chen, Jian Chen, Oliver R. Powell, Megan A. Outram, Taj Arndell, Karthick Gajendiran, Yan L. Wang, Jibril Lubega, Yang Xu, Michael A. Ayliffe, Cheryl Blundell, Melania Figueroa, Jana Sperschneider, Thomas Vanhercke, Kostya Kanyuka, Dingzhong Tang, Guitao Zhong, Catherine Gardener, Guotai Yu, Spyridon Gourdoupis, ukasz Jaremko, Oadi Matny, Brian J. Steffenson, Willem H. P. Boshoff, Wilku B. Meyer, Stefan T. Arold, Peter N. Dodds, Brande B. H. Wulff

Issue&Volume: 2025-03-28

Abstract: The role of nucleotide-binding leucine-rich repeat (NLR) receptors in plant immunity is well studied, but the function of a class of tandem kinases (TKs) that confer disease resistance in wheat and barley remains unclear. In this study, we show that the SR62 locus is a digenic module encoding the Sr62TK TK and an NLR (Sr62NLR), and we identify the corresponding AvrSr62 effector. AvrSr62 binds to the N-terminal kinase 1 of Sr62TK, triggering displacement of kinase 2, which activates Sr62NLR. Modeling and mutation analysis indicated that this is mediated by overlapping binding sites (i) on kinase 1 for binding AvrSr62 and kinase 2 and (ii) on kinase 2 for binding kinase 1 and Sr62NLR. Understanding this two-component resistance complex may help engineering and breeding plants for durable resistance.